Trio wins chemistry Nobel for work on antibody drugs, smart enzymes

Trio wins chemistry Nobel for work on antibody drugs, smart enzymes

Through the phone call, Smith, a professor emeritus at the University of Missouri-Columbia, learned that he won the Nobel Prize in chemistry for developing a method called phage display in the 1980s.

"I was not smart enough to anticipate what would come out of this research I had a narrower view than I have now", Smith said.

The Nobel Prize laureates for Medicine or Physiology 2018 are James P. Allison, U.S. and Tasuku Honjo, Japan presented at the Karolinska Institute in Stockholm, Sweden, on October 1, 2018.

In particular, Francis Arnold spent the first directed evolution of enzymes - proteins that catalyze chemical reactions.

Three scientists have won the Nobel Prize in physics for their work with lasers, including the first female Nobel laureate to be named in the physics field for 55 years.

Prof Dame Carol Robinson, president of the Royal Society of Chemistry, said that directed evolution of enzymes and antibodies "are now transforming medicine".

"Chemistry is filled with brilliant women, so I think we'll see a steady stream of Nobel prizes awarded to women", says Arnold. Morrison, who is the Robert F. Goheen Professor in the Humanities, Emerita, won the Nobel Prize in Literature in 1993 and is the only other female associated with the University to win the award.

She conducted her Nobel-winning research while still a PhD student working with Mourou in 1985 at the University of Rochester in NY.

Smith is one of three researchers who "harnessed the power of evolution" to produce enzymes and antibodies that have led to a new best-selling drug and biofuels.

Chemistry professor Michael Hecht said in a University press release that Arnold is a "powerhouse".

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Winter was chosen for his work involving the use of phage display in the production of new pharmaceuticals, such as powerful antibodies that can fight autoimmune diseases and even cancer.

The last woman before Strickland to win the physics prize, theoretical physicist Maria Goeppert-Mayer, was forced to work for years at USA universities for free, as her husband was also a scholar.

Smith, 77, is the first professor in the University of Missouri's history to win the Nobel Prize.

Smith pioneered a method known as phage display that allows researchers to find other molecules that interact with the protein on the phage.

"Very few research breakthroughs are novel".

"As a basic scientist, to have my work really impact people is just one of the best things", he said.

In the 1980s, Arnold tried to rebuild enzymes, but because they are very complex molecules built from different amino acids that can be infinitely combined, she found it hard to remodel the enzymes' genes in order to give them new properties.

Six months after being honoured by Business Weekly and Cambridge Enterprise with our inaugural Lifetime Achievement Award, Sir Greg has become the 107th affiliate of Cambridge to be awarded a Nobel Prize. "Mine was an idea in a line of research that built very naturally on the lines of research that went before".

Two years ago, in 2016, Sir James Fraser Stoddart, from the United Kingdom, won the Nobel Prize in Chemistry, nine years after winning the KFP in Science.

"It would've been nice if I got the prize like 10 years ago so a whole bunch of grant proposals that didn't get funded probably would've gotten funded", Smith said. 8 October in Stockholm will name the victor of the prize for Economics in memory of Alfred Nobel.

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