BRCA May Not Impact Survival in Young-Onset Breast Cancer

BRCA May Not Impact Survival in Young-Onset Breast Cancer

"While there is now no cure for metastatic breast cancer, today's approval offers a new, targeted option that may help to delay disease progression for these patients".

With the decision aid, half of the women scored at least 80 out of 100 on tests of their knowledge about breast cancer and treatment options, compared with a median score of 66 for women who reviewed material on various websites.

AZN received good news today when the FDA approved LYNPARZA (olaparib) for HER2-negative breast cancer patients whose tumors harbor the BRCA mutation, the first such approval worldwide.

Located within Penn Medicine's Abramson Cancer Center, The Basser Research Center for BRCA focuses exclusively on BRCA1 and BRCA2.

Eccles, MD, University of Southampton and University Hospital Southampton NHS Foundation Trust, United Kingdom, and colleagues looked at survival following treatment for the initial breast cancer diagnosed only.

The study involved 2,733 British women aged 18-40 who had been diagnosed with breast cancer between 2000 and 2008.

The BRCA1 and BRCA2 genes usually produce molecules inside cells that help to fix DNA.

On Thursday, research led by the University of Southampton concluded that BRCA-mutated breast cancer is no more unsafe or aggressive than any other form of the disease.

Abe, Ratas agree to step up pressure on N.Korea
Following Moon's remarks, the Japanese government reportedly filed a formal protest with the South Korean Embassy in Tokyo . It said it would consult with Japan on what to do with the funds already given by the country.

BRCA gene mutations are particularly susceptible to cancer, drastically increasing the risk a woman will develop breast tumors from 12 percent to 90 percent. Most importantly, they uncovered that there was no difference in overall survival two, five, or ten years after diagnosis for women with and without a BRCA mutation.

The researchers say that these findings could give women "more confidence and control" when making decisions about their treatment.

"Our study is the largest of its kind, and our findings suggest that younger women with breast cancer who have a BRCA mutation have similar survival to women who do not carry the mutation after receiving treatment", Eccles said in a press release.

The women's medical records were tracked for up to 10 years.

Women who have had breast cancer are also more likely to be diagnosed with the disease a second time if they carry these genetic faults, which is why some choose to have risk-reducing surgery such as removing the breasts. This surgery did not appear to improve their chances of survival at the 10-year mark, according to the findings published in The Lancet Oncology.

Professor Peter Fasching, from Friedrich-Alexander University Erlangen-Nuremberg, Germany, added: "This important topic needs more prospective research as preventive surgical measures might have an effect on what might be a very long life after a diagnosis of breast cancer at a young age".

Two notorious genetic mutations linked with breast cancer may not impact how long a woman will survive, a new study has found.

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