"I don't think they will be happy", Guardiola told reporters ahead of Saturday's FA Cup semi-final against Arsenal at Wembley.
The Brazil global made a stunning start to life at City, scoring three goals in his first two league games before getting injured on February 13 against Bournemouth.
"He is really much, much better", the City manager said.
"We are going to travel, all the group, to Wembley, he will be part of that and after that we'll see".
The Gunners make the short journey to Wembley with David Ospina (back), Danny Welbeck (toe), Shkodran Mustafi and Lucas Perez (thigh) all missing while Jeff Reine-Adelaide (ankle) and Santi Cazorla (Achilles) will not play again this season.
Brazil worldwide Jesus, who made an instant impact after joining City in January with three goals in four league games, returned to training earlier this month after suffering a foot injury against Bournemouth in February. Initially, he wasn't expected to return before May.
"In just 10 minutes against Tottenham he created two or three chances himself and scored (a disallowed goal)".
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On the downside for City, defender John Stones has been ruled out with the injury that prevented him from featuring in last week's Premier League victory at Southampton. They are my bosses.
"We want the FA Cup to put in my players" hearts and heads how good they are, ' he added.
"I said many times with them, but they still don't believe how good they are". It's so important. All clubs in the world want to win titles. Winning titles gives you the self-confidence to say 'we're good enough to compete'. I was so happy all the season, with up and downs.
"Winning helps you win more, because you live that experience, you win a title or a final, it's a lot of stress, a lot of pressure and if you handle that and you are able to win, the next time is a little easier".
"Because I'm a guy who if we don't play well I say we don't play well". "It's going to be important for us to finish the season strongly and hopefully have a final to look forward to". "All the squad are travelling down tomorrow and we will watch the match between Tottenham and Chelsea", he said. "After dinner I will decide the team".
United could move to within a point of Guardiola's side if they can beat Burnley on Sunday, leaving the derby to potentially decide which of the two Manchester clubs qualifies for next season's Champions League.
Guardiola said of Stones: "The problem is muscular, (he was hurt) one day in a training session. Maybe he come back for [Manchester] United [on Thursday], but I don't know".