Undoubtedly Dortmund should not have been made to play the first leg less than 24 hours after their team bus was attacked and the 3-2 defeat in the first leg will probably prove too big of a gap for Thomas Tuchel's side to overcome tonight.
But any thoughts of a revival were ended by Germain, another replacement, as he converted following a swift Monaco break only 22 seconds after taking the field in place of Mbappe.
Dortmund last reached the last-four stage in 2013, when they went on to lose in the final to Bayern Munich.
"But after 16 or 17 minutes nothing had happened and we asked why we were not moving".
The midfielder won't be playing Wednesday either, when Monaco host Borussia Dortmund in their Champions League quarterfinal.
Only Barcelona and Bayern Munich (4) have been awarded more penalties than Monaco (3) in this season's Champions League. What we must avoid is losing the ball as easily as we did for Monaco's third goal in the first leg.
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The 18-year-old was a lively presence throughout as goals from fellow strikers Radamel Falcao and Valere Germain saw Monaco through to the semi-finals - where they could face Real Madrid, Juventus or Atletico Madrid - but Mbappe is unconcerned about the prospects of Friday's draw.
They also meet PSG in a mouth-watering Cup semi-final on April 26 but the first thing on their minds will surely be to try to emulate their 2004 Champions League achievement, when they reached the final and lost 3-0 to Porto. "They will have gotten over the events of last week, and they'll have [Gonzalo] Castro and [Marco] Reus back, two very important players", he said. Prior to Wednesday's game, Dortmund's bus was held for almost 20 minutes by police at the team hotel. We play attacking football.
Much like in the first leg, the action was end to end and Bernardo Silva crashed a free header straight at Burki, while at the other end Sahin saw a curling 25-yard free-kick hit the inside of the right post and bounce clear.
"I had the feeling we were focused and full of joy and happiness to play this game".
"I feel valued and supported by everyone in the club, by the players and from the supporters", Falcao said. I think the players are ready and are working well.
With Dortmund pushing forward in numbers, Monaco was stretched down both flanks but, equally, it was left exposed to Monaco's slick counterattacking.