The Bianconeri played a style of football that is suited to them and did it very well.
That stunning result eventually led to the replacement of coach Rafa Benitez by Zinedine Zidane, the former Madrid and France great who had never held a head-coaching job. "But my best memory was when we had just won the Spanish league, and the first game after we'd won the league, we played Barcelona at home".
Barcelona has won two of the last three games against Madrid at the Bernabeu, including 4-0 in the league two seasons ago.
Second-placed Barca take on league leaders Real on Sunday knowing a win could take them top of the table, and Twitter has released a set of temporary Clasico-themed emojis for fans to use online to mark the occasion. While the Trio is expected to start against Real Madrid.
Since then, Barcelona has won three titles and Atletico Madrid one.
Barcelona have had their attempts to overturn the ban knocked back.
Messi led from the front as Barca could only draw 0-0 to Juventus and was at the heart of his side's best chances, but it was not to be as he saw two shots flash just wide and another saved by Gianluigi Buffon.
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They effectively sealed their title with a late victor by Cristiano Ronaldo, who celebrated by mischievously gesturing the 99,000 Barcelona supporters inside the Nou Camp to calm down.
Aleix Vidal is out for the rest of the season.
The Wales global suffered a calf injury in the 2-1 UEFA Champions League quarter-final, first-leg win over Bayern Munich at the Allianz Arena on April 12. "We have to get ready and compete and I am sure we will do that".
Such was the case for Real Madrid last time out when 41% ($1.7m) of the total media generated for their sponsors came from the club's social platforms - Facebook, Instagram, Twitter and YouTube.
For defenders they are remarkably prolific and it would not be odd if, despite all the attacking talent on show at the Santiago Bernabeu on Sunday, one of them ended up settling the game. The season will be over bar a Copa del Rey final against Alaves at the end of the season.
There will be no guard of honour on Sunday-it's still too early for that-but a Madrid win might effectively seal yet another league title, and a long overdue one at that.