Marko Pjaca is expected to stand in for Cuadrado. Young Donnaruma, the goalkeeper of Milan screamed after the match during the moments when the home team's players celebrated. In fact, Milan were fortunate not to concede an early penalty when centre back Christian Zapata's trailing leg caught Dybala in the box but the referee chose to play advantage instead of pointing to the spot.
Medhi Benatia struck inside 30 minutes for Juventus as he intercepted a Milan counter attack, completing a series of one-twos before burying the ball in the back of the net.
The second half kick-started with Juventus dominating Milan and were almost rewarded when midfielder Pjanic's cross was deflected on to the cross bar only landing a corner for the Bianconeri.
The teams' current form and recent history suggests Juventus fans will leave their stadium smiling.
The 18-year-old Milan goalkeeper produced a superb double save when he parried Sami Khedira's shot and then tipped Gonzalo Higuain's effort around the post from the rebound.
The penalty was awarded for handball by Mattia De Sciglio although Stephan Lichtsteiners cross hit him at point-blank range and, in any case, appeared to strike his stomach rather than his hand.
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Asamoah was fouled in the 93rd minute by Jose Sosa who picked up a second yellow card for that reckless tackle and got sent off.
Dybala stepped up and scored a textbook spot-kick, winning the game with virtually the last kick of the game and despite Donnarumma guessing the direction, for once the keeper could not do anything.
Juventus, meanwhile, moved 11 points clear at the top of the Serie A table with victory, asserting their dominance in their hunt for a sixth successive Scudetto.
Espanyol twice relinquished leads and still beat Las Palmas 4-3 in the Spanish league Friday, keeping alive its hopes of qualifying for the Europa League next season.
Gab Marcotti examines the controversial penalty decision in stoppage time that saw Juventus past AC Milan.